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Variant influenza A virus infections are infections in people with influenza A viruses that normally spread in pigs and not in people. Every year, there are rare, sporadic human infections reported with influenza A viruses that usually spread in pigs and not in people. Most variant influenza A virus infections are associated with exposure to infected pigs, but some variant virus infections occur in people who do not report having animal exposure.
The Centers for Disease Control and Prevention (CDC) recommends that people in contact with pigs take precautions and provides specific guidance for people who are at higher risk of developing serious complications from flu. CDC also has also provided guidance for clinicians on the identification and treatment of variant influenza A virus infections in people and recommendations for fair exhibitors and organizers.
When a virus that normally spreads in pigs is found in people, these are called "variant influenza A virus" infections and are designated with the letter "v" after the subtype. Most human infections with variant influenza A viruses occur following exposure to infected swine, but limited person-to-person spread has occurred. However, in most cases, variant influenza A viruses have not shown the ability to spread easily and sustainably from person to person.
Variant influenza A virus infections usually cause mild illness; however, they can cause severe illness, especially in people who are at higher risk for serious flu complications. Many variant influenza A virus infections have occurred in people who have had contact with pigs at agricultural fairs. These infections are fully investigated to ensure that these viruses are not spreading efficiently in people and to limit further exposure of people to infected animals.
CDC has more information about how variant virus infections happen. CDC also has web resources and additional background information available.