The One & Only Campaign


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What you need to know

The One & Only Campaign is a public health effort, led by the Centers for Disease Control and Prevention (CDC) and the Safe Injection Practices Coalition (SIPC), to raise awareness among patients and healthcare providers about safe injection practices.

The Campaign aims to eliminate infections resulting from unsafe injection practices. 

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    Since 2001, more than 150,000 patients in the United States have been notified of potential exposure to hepatitis B virus (HBV), hepatitis C virus (HCV), and HIV due to lapses in basic infection control practices.

    Many of these lapses involved healthcare providers reusing syringes, resulting in contamination of medication vials or containers which were used then on subsequent patients. 

    Make every injection a safe one.


    The goal of the One & Only Campaign is to ensure patients are protected each and every time they receive a medical injection. This will be attained by empowering patients and re-educating healthcare providers regarding safe injection practices. Targeted education and awareness campaigns focus on influencing the culture of patient safety. Patients and providers must both insist on nothing less than One Needle, One Syringe, Only One Time for each and every injection. This practice will greatly reduce the risk of contracting hepatitis and other infections through medical injection. The SIPC and One & Only Campaign are made possible by a CDC Foundation partnership with Eli Lilly and Company

    Anticipated outcomes of the One & Only Campaign include:

    • Increased awareness among the general public and healthcare providers about safe injection practices;
    • Increased patient involvement/empowerment as a strategy to promote healthcare provider adherence to safe injection practices; and
    • Increased understanding and implementation of safe injection practices among healthcare providers.
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    Hear Evelyn's Story about her health crisis resulting from unsafe injection practices​.

    Managing Patient Safety, One Injection at a Time - VIDEO

    Watch this educational video on Safe Injection Practices


    Use the CDC's Injection Safety Checklist

    This checklist, developed by CDC and the Safe Injection Practices Coalition, includes nine observations to help healthcare workers ensure they are adhering to safe injection practices during the care of patients. 

    Injection Safety Checklist


    When in Doubt, Throw it Out!

    CDC recommends the following injection safety practice:  When you administer an injection, carefully check the label of the vial. If it says single-dose and has already been accessed, throw it away. 

    Single dose vial education


    State Injection Safety Resources

    Nebraska DHHS Healthcare Associated Infections (HAI) Program

    The HAI team of the Epidemiology Unit of DHHS is tasked with helping to decrease the incidence of HAIs in Nebraska by:

    • Monitoring the occurrence of HAI's in local hospitals
    • Tracking antibiotic resistance
    • Working with the ICAP Program to assess and promote quality infection control at health
      care facilities
    • Coordinating the state HAI Advisory Committee
    • Developing an HAI Outbreak Detection and Management Program
    • Supporting efforts in Antibiotic Stewardship
    • Managing a website with HAI information for the public and healthcare professionals


    More Resources

    Nebraska Infection Control Assessment and Promotion Program (ICAP)

    Nebraska ICAP is CDC-funded partnership between Nebraska Medicine, the University of Nebraska Medical Center and the Nebraska DHHS HAI/AR Program. Since 2015, the team has performed assessments in over 150 Nebraska healthcare facilities, all across the healthcare continuum.  In each facility, our experienced infection prevention team shares the latest evidence-based infection control practices and strategies. Promotion of safe injection practice resources is a core activity and great passion of the team, and includes direct dialogue among infection preventionists about relevant risks in healthcare facilities. For more information and useful tools and links, visit the ICAP website at

    The Nebraska Infection Control Network (NICN)

    The NICN was founded in 1980 by Philip W. Smith, MD. Its mission was to improve the quality of healthcare in Nebraska hospitals, long term care facilities and communities through the prevention and control of infectious diseases. The NICN uniquely combines the volunteer efforts of key agencies and emphasizes educational programs. In the more than 30 years these courses have been provided, over 4000 trainees have attended.

    The intensive two-day Primary Infection Prevention course is held twice a year in Omaha and has included an injection safety lecture since 2017.  

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    Margaret Drake MT, ASCP, CIC 
    Infection Preventionist and Safe Injection Activity Contact
    Phone Number
    (402) 471-7010

    M. Salman Ashraf, MBBS
    Medical Director, Healthcare-Associated Infections and Antimicrobial Resistance Program 
    Phone Number
    (402) 219-3115