Nebraska State Immunization Information System (NESIIS)
    Data Exchange



Electronic Submission of Immunization Records
The electronic reporting of immunization data is a public health core objective for eligible hospitals, critical access hospitals (CAH), and eligible professionals attesting to Stage 3 Meaningful Use (MU). 
The Nebraska State Immunization Information System (NESIIS) is an immunization system designed to consolidate patient immunization records into one complete, accurate and definitive immunization record.
Currently, NESIIS receives data from hospital systems, vital records, local health departments, private providers, public immunization clinics, and other health care facilities. The data provided by NESIIS is intended to give individuals, families and health care professionals the tools needed to make sound medical decisions.

NESIIS is able to do the following:

  • Uni-directional Data Exchange
  • Bi-directional Data Exchange

What is bi-directional exchange? In order to be bi-directional with NESIIS, you must be able to query patient records in NESIIS from within your EHR interface. An example of this would be pulling up a record in your EHR, then clicking a button to query NESIIS for that same person's record to see if additional information can be found.

For more information regarding bi-directional data exchange with NESIIS please contact our Help Desk at 888-433-2510 or  

Information on bi-directional support is found within our HL7 specifications.

  •  Accept and send HL7 2.3.1 formatted data
  •  Accept and send HL7 2.5.1 formatted data
  •  Accept and send data electronically via PHINMS and SOAP Web Services 
View a complete list of participating facilities.
Please see the links below for more details on the specifications and requirement for electronic immunization data exchange. 


Steps to Data Exchange

NESIIS Web Services Info/ Specifications

NESIIS HL7 2.4 Data Exchange Specifications 

NESIIS HL7 2.5.1 Data Exchange Specifications


Contact Information 1-888-433-2510 or 402-471-0133

Documents in PDF PDF format require the use of Adobe Acrobat Reader,
which can be downloaded for free from
Adobe Systems, Inc.